Coronary Vasoconstriction: Visible and Invisible

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Abstract
RESEARCH often proceeds in waves produced by observations that open new avenues for investigation. Over the past decade the finding that vascular tone can be modulated by vasoactive substances released by endothelium1 has influenced biologic, physiologic, and clinical research. The observation that vasodilator stimuli can cause constriction of an artery after the removal or injury of the endothelium supported the notion that endothelial dysfunction is the most important cause of inappropriate vasoconstriction.In cardiology this interesting line of research merged with another, which also began in the 1980s after it was observed that coronary stenoses can often dilate or constrict . . .