Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids

Publisher Website
Google Scholar
Abstract
A series of (mercaptoaroyl)amino acids and related compounds was synthesized and tested for ability to inhibit angiotensin converting enzyme (ACE). The most active compound was N-(3-chloro-2-mercaptobenzoyl)-N-cyclopentylglycine, having an in vitro I50 [medium inhibitory concentration] = 0.28 .mu.M. Substitution of the aromatic 3-position by small polar groups enhanced ACE inhibitory activity, whereas bulky group diminished it. Alteration of the .beta. relationship between the mercaptan and amide carbonyl or masking of the thiol by acylation reduced activity. Replacement of the thiol by nitro, hydroxy or carboxy gave compounds lacking ACE inhibitory activity.