Early Effects of Beta Irradiation on Dermal Vascular Permeability to Plasma Proteins

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Abstract
Vascular changes in guinea pig skin after [beta]-irradiation with a Sr90-Y90 sealed source were studied by injection of I125_iabeied serum albumin. There was a progressive increase in intravascular plasma volume which reached a maximum, 124% of the control, at 18 hr. and persisted for 48 hrs. after 3000 rep of [beta]-irradiation. A biphasic increase in the transfer rate of plasma protein from blood vessels into extravascular space in epidermis and dermis was evident by 24 hrs. in 3000 rep of [beta]-irradiated skin. The first peak increase in epidermis and dermis of 36% and 17%, respectively, occurred 3 hrs. postirradiation; this was followed by a decline to almost the control level and a second peak increase of 84% in epidermis and 37% in dermis at 18 hrs. Eighteen hrs. after 3000 rep of fi -irradiation, plasma protein accumulation in dermis and epidermis was 2.2 and 3.7 times that in the control area, but there was no significant difference between irradiated and control skin at 48 hrs. Some increase in plasma protein accumulation was also observed at 18 hrs. after 500 rep and 1000 rep of [beta]-irradiation. The data indicate that [beta]-irradiation with a single skin surface dose of 500 to 3000 rep causes an immediate increase in intravascular volume as well as vascular permeability to plasma protein.

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