The role of the arginine-B22 residue in insulin action
- 1 June 1981
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 195 (3) , 765-768
- https://doi.org/10.1042/bj1950765
Abstract
The modification of the side chain of the arginine-B22 residue of insulin by the N8N9-(1,2-dihydroxycyclohex-1,2-ylene) group and by the adipoyl group is described. These are the 1st insulin derivatives described that contain a modified arginine residue in an otherwise unaltered molecule. When tested for their ability to lower rat blood sugar concentration, both modified insulins showed a specific activity indistinguishable from that of insulin. As the substituent groups involved are very bulky and in 1 case of opposite charge to that of the side chain, the retention of biological activity casts doubt on the idea, previously generally accepted, that the arginine-B22 residue is essential to the activity of the hormone.This publication has 11 references indexed in Scilit:
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