Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis
- 10 May 2005
- journal article
- review article
- Published by Taylor & Francis in Emerging Drugs
- Vol. 10 (2) , 299-310
- https://doi.org/10.1517/14728214.10.2.299
Abstract
The development of specific targeted therapies, such as anti-TNF-α treatment, for chronic inflammatory disorders such as rheumatoid arthritis, has significantly improved treatment, although not all patients respond. Targeting cellular adhesion molecules and chemokines/chemokine receptors as regulators of the extravasation and migration of leukocytes may provide a novel approach for the treatment of these diseases. Moreover, the possibility of developing small-molecule antagonists offers an excellent method for the oral delivery of compounds with a short half-life.Keywords
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