Comparison of Gd-BOPTA with Gd-DTPA in MR imaging of rat liver.

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Abstract
A new lipophilic compound, gadolinium benzyloxypropionictetraacetate (BOPTA), with a high rate of biliary excretion was assessed as magnetic resonance (MR) hepatospecific contrast-enhancing agent and compared with Gd-DTPA (diethylentriamineepetanacetic acid) in MR imaging of normal rats. T1-weighted spin-echo showed greater enhancement of the contrast agent at doses of 0.25, 0.5, and 1.0 mmol/kg images obtained before and after administration of each liver with Gd-BOPTA than with Gd-DTPA, with the advantage more evident at lower doses. Images obtained with an inversion recovery sequence at the null value of rat liver parenchyma after injection of 0.1-0.5-mmol/kg doses of the contrast agent provided better evidence of the greater and longer-lasting hepatic enhancement due to Gd-BOPTA when compared with that of Gd-DTPA. Gd-BOPTA is a potentially good contrast agent for obtaining prolonged enhancement of the liver, permitting studies during the long time needed to acquire conventional T1-weighted images.

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