Effect of Route of Administration of Vaccine and Challenge on the Immunogenic Efficiency of Double Vaccination with Irradiated Ancylostoma caninum Larvae

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Abstract
Double subcutaneous vaccination of pups aged 3 and 4 months with 1,000 40-kr-irradiated Ancylostoma caninum larvae is more effective than double oral vaccination with the same preparation when resistance is measured by the establishment of adult hookworms resulting from an experimental challenge of normal larvae. In terms of resistance to the pathogenic effects of the challenge, as demonstrated by hemato-logic and coprologic findings and by clinical observation, both methods of vaccination are equally effective in protecting the vaccinates when compared with the severely affected challenge control dogs. The results suggest that the arrest of X-irradiated larvae in some somatic location on their migratory route following subcutaneous inoculation produces a better immunogenic stimulation of the host.