Severe Pneumonitis Occurring During Methotrexate Therapy
- 1 February 1971
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 103 (2) , 194-197
- https://doi.org/10.1001/archderm.1971.04000140080014
Abstract
Two patients with serious skin diseases were treated with intermittent, intramuscularly administered methotrexate in doses of 50 to 75 mg. Fever, cough, dyspnea, and bilateral noninfectious pulmonary infiltrates developed in both patients after several weeks of therapy. The respiratory illness were attributed to a pulmonary reaction, possibly allergic in nature, produced by methotrexate. Previous instances of pulmonary infiltrates secondary to methotrexate have been reported only in leukemic patients receiving intermittent therapy.Keywords
This publication has 1 reference indexed in Scilit:
- Recurrent Pulmonary Infiltration and Pleural Effusion Due to Nitrofurantoin SensitivityNew England Journal of Medicine, 1962