TSPY variants in six loci on the human Y chromosome
- 1 July 2000
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 91 (1-4) , 67-71
- https://doi.org/10.1159/000056821
Abstract
We have studied the structure, organization, and evolution of the human TSPY gene family by mapping three sequence variants identified through RT-PCR analysis onto genomic clones derived from two different YAC contigs. TSPY gene family members occur in at least six locations on the human Y chromosome, and each cluster contains a unique combination of variants. Our data further suggest that an 18-bp tandem duplication found in TSPY exon 1 originated from an unequal sister chromatid exchange between two tandemly arranged TSPY clusters.Keywords
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