Polymeric Microcapsules for Drug Delivery

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Abstract
Microencapsulation is a technique of enclosing a core material into a polymeric membrane such that the encapsulate may be released over a period of time by diffusion or spontaneously on collapsing the wall by a sudden pressure. Besides being used in the dye, food and chemical industries, such a technique has applications in biomedicine for prolonged drug delivery. Cellulose acetate may be used as an encapsulating material giving microcapsules for sustained drug delivery. The conditions of formation of such capsules containing testosterone and its subsequent release from depots are described. Scanning electron micrographs of these show formation of good, nearly spherical capsules in the range of 5-100 .mu.m. Testosterone release from the microcapsules sustains up to 35 days. Possible medical applications are discussed.

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