Susceptibility of anaerobic bacteria to Sch 29482

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Abstract
The activity of Sch 29482 (SCH) was determined against 103 clinical isolates of anaerobic bacteria by an agar dilution method. Its activity was compared with that of cefoperazone, cefoxitin, moxalactam, chioramphenicol, clindamycin and metronidazole. Bacteria included 27 strains of the Bacteroidesfragilis group which on prior testing had MICs of cefoperazone of ≥ 32 mg/l. The remainder were a random selection of strains isolated in 1980. SCH inhibited the majority of strains at ≧2 mg/l. One Peptococcus required 4 mg/l and one Bact.fragilis required 8 mg/l for inhibition. On a weight basis SCH was generally more active than the other β -lactam antibiotics, chioramphenicol and metronidazole. It showed activity equivalent to or better than clindamycin with most of the strains. On the basis of these results, SCH appears to be a promising antimicrobial agent for anaerobic infections and warrants further study.