Mammary Gland Development After Hypophysial Isografts in Intact Mice of High and Low Mammary Cancer Strains2

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Abstract
A single hypophysial isograft in intact mice induced pseudo-pregnancy-like vaginal cycles and mammary gland development in females of the C57BL, A, CE, C3H, CBA, and RIII strains of mice and in (CBA × RIII), (RIII × CBA), and (RIII × A)F1 hybrids. Mammary gland development was also observed in male (RIII × CBA) and (RIII × A)F1 hybrids bearing hypophysial grafts. There was a marked strain difference in the extent of mammary gland development in the hypophysial grafted mice. A slight difference was noted in the mammary glands of controls from the various strains. Morphological correlation could not be made between the extent of mammary gland development in control or hypophysial grafted mice and the spontaneous incidence of mammary cancer in the various strains. Hypophysial grafts in (RIII × CBA)F1 females became neoplastic after 240 days. Mammary carcinoma was noted in male (RIII × CBA)F1 hybrids after long-term exposure to hypophysial graft stimulation.