Biosynthesis of vitamin B12
- 27 September 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 331 (1-2) , 105-108
- https://doi.org/10.1016/0014-5793(93)80306-f
Abstract
In the vitamin B12 biosynthetic pathway the enzymes responsible for the conversion of precorrin-3 to precorrin-4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans. CobG catalyzes the oxidation of precorrin-3 to precorrin-3x (a hydroxy lactone) whereas CobJ is a SAM-dependent C-17 methyl transferase and is necessary for ring contraction. A mechanism for ring contraction is proposed.Keywords
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