Early Replication of Friend Leukaemia Viruses in Spleen Macrophages

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Abstract
The ability of spleen macrophages to support Friend leukemia virus replication was studied by testing for infectivity in adherent cells obtained from mice at various times after infection. Virus-releasing macrophages appeared early after infection and reached a high proportion. The released virus was probably synthesized de novo since macrophage infectivity was strongly reduced by treatments which affected cellular viability or synthetic activities and EM showed C-type particles budding from macrophages.