VERY HIGH DOSE INTRAVENOUS GAMMAGLOBULIN IN THROMBOCYTOPENIA OF PREGNANCY
- 1 April 1989
- journal article
- Published by Wiley in Australian and New Zealand Journal of Medicine
- Vol. 19 (2) , 151-153
- https://doi.org/10.1111/j.1445-5994.1989.tb00229.x
Abstract
A 22‐year‐old woman with severe idiopathic thrombocytopenic purpura, complicating pregnancy, was unresponsive to high‐dose corticosteroids and three separate infusions of high‐dose intravenous immunoglobulin using the conventional schedule of 400 mg/kg/d for five days. A dramatic albeit transient, elevation of her platelet count followed a six day course of very high dose immunoglobulin (1000 mg/kg/d) thus allowing elective lower segment cesarean section to be performed without complications and with the delivery of a live, female infant. Two months later a further course of very high dose gammaglobulin was again effective in raising the patient's platelet count prior to elective splenectomy. No adverse reactions were seen to either infusion.Keywords
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