New bioimpedance analysis system: improved phenotyping with whole-body analysis

Abstract
Objective: Bioimpedance analysis (BIA) is a potential field and clinical method for evaluating skeletal muscle mass (SM) and %fat. A new BIA system has 8-(two on each hand and foot) rather than 4-contact electrodes allowing for rapid 'whole-body' and regional body composition evaluation. Design: This study evaluated the 50 kHz BC-418 8-contact electrode and TBF-310 4-contact electrode foot–foot BIA systems (Tanita Corp., Tokyo, Japan). Subjects: There were 40 subject evaluations in males (n=20) and females (n=20) ranging in age from 6 to 64 y. BIA was evaluated in each subject and compared to reference lean soft-tissue (LST) and %fat estimates in the appendages and remainder (trunk+head) provided by dual-energy X-ray absorptiometry (DXA). Appendicular LST (ALST) estimates from both BIA and DXA were used to derive total body SM mass. Results: The highest correlation between total body LST by DXA and impedance index (Ht2/Z) by BC-418 was for the foot–hand segments (r=0.986; left side only) compared to the arm (r=0.970–0.979) and leg segments (r=0.942–0.957)(all Pr0.95, Pr=0.96, Pvs DXA (r=0.87, Pr=0.82, P<0.001). Group mean segmental %fat estimates from BC-418 did not differ significantly from corresponding DXA estimates. No between-method bias was detected in the whole body, ALST, and skeletal muscle analyses. Conclusions: The new 8-electrode BIA system offers an important new opportunity of evaluating SM in research and clinical settings. The additional electrodes of the new BIA system also improve the association with DXA %fat estimates over those provided by the conventional foot–foot BIA.

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