High-Level Acetaldehyde Production in Lactococcus lactis by Metabolic Engineering
Open Access
- 1 February 2005
- journal article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 71 (2) , 1109-1113
- https://doi.org/10.1128/aem.71.2.1109-1113.2005
Abstract
Efficient conversion of glucose to acetaldehyde is achieved by nisin-controlled overexpression of Zymomonas mobilis pyruvate decarboxylase ( pdc ) and Lactococcus lactis NADH oxidase ( nox ) in L. lactis . In resting cells, almost 50% of the glucose consumed could be redirected towards acetaldehyde by combined overexpression of pdc and nox under anaerobic conditions.Keywords
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