Mycobacterial ribonucleic acid: comparison with mycobacterial cell wall fractions for regression of murine tumor growth

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Abstract
Mycobacterial RNA and cell wall skeleton fraction isolated from H37Ra caused P-815 mastocytoma regression in DBA/2 mice provided the animals were presensitized with freshly harvested living H37Ra cells. In the absence of presensitization, only the RNA fraction inhibited. Cell wall skeleton fraction under these conditions stimulated tumor growth. Cell wall lipids (from H37Ra) added to H37Ra cell wall skeleton fraction did not increase the inhibitory activity of cell wall skeleton fraction alone. Mycobacterial RNA appeared to be an effective inhibitor of P-815 mastocytoma metastases as shown by the inhibition of a 2nd footpad lesion distanct from the 1 treated and increase in survival time.