IMMUNE-COMPLEX GLOMERULONEPHRITIS IN MICE INFECTED WITH ESCHERICHIA-COLI

  • 1 January 1980
    • journal article
    • research article
    • Vol. 42  (1) , 77-85
Abstract
C57Bl/6 mice were injected i.p. with 108 to 2 .times. 108 living K 38 E. coli; serological changes and kidney involvement were studied. E. coli were found in the blood 45 min to 24 h after injection. In serum, large amounts of DNA were present 24 h after E. coli injection, and thereafter disappeared. Seven days after infection, antibodies directed against E. coli, anti-DNA antibodies and C1q[q fragment of complement component 1]-binding substances were found in serum; the kinetics of the variations of these parameters were studied until day 35. Kidney lesions were evaluated immunochemically and by optical microscopy and EM. In the glomeruli, heavy granular deposits of IgG and IgM were constantly found in mesangium and along capillary walls. In most kidneys slight granular deposits of IgG and IgM were also found in the tubules. Histological studies revealed in the glomeruli mild endocapillary cell proliferation, focal thickening of glomerular basement membrane and dense deposits in mesangial and subendothelial areas and inside the glomerular basement membrane; in the tubules dense deposits were focally observed inside the tubular basement membrane.

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