Circulatory changes following angiotensin administration

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Abstract
The effect of angiotensin on normal dogs, pregnant dogs, Na depleted dogs, and aldosterone-loaded dogs was studied. Mean arterial pressure (MAP), mean right atrial pressure (MRAP), mean left atrial pressure (MLAP), mean pulmonary arterial pressure (MPAP), and cardiac output were followed throughout each experiment. The MAP of the normal dogs increased 39%, the MAP of the pregnant dogs increased 23%, the MAP of the sodium-depleted dogs increased 22%, and the MAP of the aldosterone-loaded dogs increased 42% when they received 0.1 [mu]gAg angiotensin. The cardiac output decreased more than 10% in all the animals following the injection of angiotensin. Other significant findings were: the MRAP increased from 1.5 to 2.0 mm Hg in the animals pretreated with aldosterone; and the MLAP rose from 2.3 to 3.8 mm Hg in the Na-depleted dogs, and from 2.2 to 4.0 mm Hg in the dogs pretreated with aldosterone. The MPAF rose from 12.0 to 15.8 mm Hg in the dogs pretreated with aldosterone. The pregnant and sodium-depleted animals showed a decreased (P<0.05) pressor response to angiotensin.