REDUCED VASCULAR RESPONSE TO ANGIOTENSIN II IN SECONDARY HYPERALDOSTERONISM*
Open Access
- 1 September 1963
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 42 (9) , 1411-1420
- https://doi.org/10.1172/jci104826
Abstract
The vascular sensitivity to intravenous angiotensin II has been compared in a group of 9 control subjects and in 14 patients with secondary hyperaldosteronism. Patients with secondary hyperaldosteronism had a diminished vasoconstrictor response to angiotensin snown by smaller rises in arterial blood pressure and in systemic vascular resistance. This was specific for angiotensin as 1-norepinephrine produced comparable changes in both groups.Keywords
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