Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.
Open Access
- 1 October 1985
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 76 (4) , 1692-1694
- https://doi.org/10.1172/jci112156
Abstract
Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats. Unconditioned media containing mitogen had no activity. Conditioned media also induced diabetes in resistant W-line BB/W rats but not in Wistar Furth rats. A soluble factor may activate a BB lymphocyte population that promotes diabetes.This publication has 9 references indexed in Scilit:
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