Oral zinc therapy of acne. Absorption and clinical effect

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Abstract
In a double-blind controlled comparison that lasted 8 wk, tablets of zinc sulfate monohydrate, 411 mg total daily dosage, and a lactose placebo were administered orally to 22 male subjects with moderate acne. Levels of Zn were determined in serum and urine. There were no statistically significant differences in the lesion counts (papules, pustules, open comedones and closed comedones) in the Zn-treated and lactose-treated cases, despite evidence in serum and urine of absorption of Zn. Oral Zn therapy has no early clinical effect on male patients with moderate acne.

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