Monoclonal Antibodies to Human β-Interferon Produced by Adoptive Transfer in Irradiated Mice
- 1 February 1986
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 6 (1) , 59-65
- https://doi.org/10.1089/jir.1986.6.59
Abstract
Three murine anti-human β-interferon (IFN-β) monoclonal antibodies have been isolated following adoptive transfer of immune spleen cells. Adoptive transfer was used to increase the specific efficiency of the fusion. These antibodies have been used to define two epitopes on IFN-β; the antiviral, antiproliferative, and immunomodulatory effects of IFN-β are associated with one of these epitopes.Keywords
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