Immune response to virus-infection-associated (VIA) antigen in cattle repeatedly vaccinated with foot-and-mouth disease virus inactivated by formalin or acetylethyleneimine
- 1 February 1979
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 82 (1) , 41-50
- https://doi.org/10.1017/s0022172400025456
Abstract
SUMMARY: The results of experiments to investigate antibody to ‘virus infection associated’ (VIA) antigen in cattle repeatedly vaccinated with formalin- or acetylethyleneimine- (AEI) inactivated foot-and-mouth disease (FMD) vaccines under laboratory conditions are reported. Results are also presented from some vaccinated animals subsequently exposed to FMD infection.Antibody against VIA was not detected before and after the first vaccination with formalin or AEI-inactivated vaccine but did develop in all animals after the second formalin vaccination and persisted throughout the experiment. After the second AEI vaccination, 4 of 12 animals developed antibody which persisted for at least 37 days. This transient response in some cattle was repeated after successive vaccinations but, in general, more animals responded as the number of vaccinations increased.After exposure to infection, a transient VIA antibody response was occasionally observed in immune AEI-vaccinated animals. Some immune repeatedly AEI-vaccinated cattle did not develop detectable VIA antibody after challenge despite the persistence of virus in oesophageal–pharyngeal (O/P) fluid.The presence of antibody to VIA antigen is not conclusive proof that vaccinated animals have been exposed to infection and field data must be interpreted with caution.This publication has 14 references indexed in Scilit:
- CHEMICAL INACTIVATION OF FOOT-AND-MOUTH DISEASE VIRUSAnnals of the New York Academy of Sciences, 2006
- The detection of antibody to virus-infection associated (VIA) antigen in various species of African wildlife following natural and experimental infection with foot and mouth disease virusArchiv für die gesamte Virusforschung, 1978
- Radial immuno-diffusion and serum-neutralisation techniques for the assay of antibodies to swine vesicular diseaseResearch in Veterinary Science, 1976
- Evidence for an Internal Antigen in Foot-and-Mouth Disease VirusJournal of General Virology, 1969
- A third antigenic component associated with foot-and-mouth disease infectionVirology, 1966
- Growth of Foot-and-Mouth Disease Virus in Monolayer Cultures of Calf Thyroid CellsNature, 1966
- The use of acetylethyleneimine in the production of inactivated foot-and-mouth disease vaccinesEpidemiology and Infection, 1963
- FORMALDEHYDE INACTIVATION OF FOOT-AND-MOUTH DISEASE VIRUS AS APPLIED TO VACCINE PREPARATION1963
- Polyoma transformation of hamster cell clones—an investigation of genetic factors affecting cell competenceVirology, 1962
- The inactivation of foot-and-mouth disease virus by formalinArchiv für die gesamte Virusforschung, 1957