ANTAGONISM BETWEEN POSTERIOR PITUITARY SECRETION AND ACETYLCHOLINE

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Abstract
Dogs were anesthetized with ether, chloretone, morphine, and nem-butal. Intraven. injs. of 0.005-Iccm. of pitressin inhibit more or less completely the depressor effects of 1-2 [gamma] of acetyl-choline. Stimulation of the central vagi, which according to Lim and collaborators produces an output of posterior pituitary secretion, is followed by a diminished depressor response to acetyl-choline. This phenomenon is abolished by section of the pituitary stalk or by severing of the brain stem. The effectiveness of such small amts. of pituitrin as are liberated by central yagal stimulation suggests a normal physiological antagonism between the post, pituitary and the para-sympathetic nervous system. Under adequate exptl. conditions this may be used as a sensitive test for the presence of small amts. of pituitary secretion in the circulation. Pitressin inhibits secretion of the sub-maxillary gland and affects the vagus response of the heart.

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