OBSERVATIONS ON THE URINARY EXCRETION OF SULFADIAZINE
Open Access
- 1 September 1943
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 22 (5) , 659-672
- https://doi.org/10.1172/jci101438
Abstract
The greatest and most prolonged increase in excretion of sulfadiazine resulted from the adm. of NaHCO3 in amts. sufficient to insure a highly alkaline urine. A decrease in the conc. of the drug in the urine was obtained most rapidly by the intraven. inj. of a large volume of 5-10% glucose soln. in distilled water. The ingestion of water in large amts. produced a similar result somewhat less rapidly. The intraven. infusion of physiological saline gave a less marked reduction in the conc. of drug in the urine and the effect was more delayed. Only the first of these 3 procedures was accompanied by a large increase in drug output.This publication has 5 references indexed in Scilit:
- OBSERVATIONS ON THE ABSORPTION, EXCRETION AND DISTRIBUTION OF SULFANILAMIDE, SULFAPYRIDINE, SULFATHIAZOLE AND SULFAMETHYLTHIAZOLEAnnals of Internal Medicine, 1941
- The Influence of Dietary Protein on the Toxicity of SulfanilamidePublic Health Reports (1896-1970), 1941
- OBSERVATIONS ON THE PHARMACOLOGY AND TOXICOLOGY OF SULFATHIAZOLE IN MANThe Lancet Healthy Longevity, 1940
- A BIOCHEMICAL STUDY OF PATIENTS ON SULPHANILAMIDE THERAPY.1939
- OBSERVATIONS ON THE ETIOLOGY OF THE TOXEMIAS OF PREGNANCY. II. PRODUCTION OF ACUTE EXACERBATION OF TOXEMIA BY SODIUM SALTS IN PREGNANT WOMEN WITH HYPOROTEINEMIAThe Lancet Healthy Longevity, 1937