Inhibitory Effect of Polynucleotides on Solid Tumor Produced in Mice by Ehrlich Ascites Cancer Cells
- 1 January 1982
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 2 (1) , 103-105
- https://doi.org/10.1089/jir.1982.2.103
Abstract
Solid tumors produced in mice by Ehrlich ascites cancer cells were completely regressed by treatment with the copolymer of polyriboinosinic acid-polyribocytidylic acid (poly (I):(C)) when 200 μg of this compound was intravenously injected 3 times a week for 3–4 weeks, starting 7–8 days after transplantation of the tumor. Although the first injection of poly (I):(C) caused hyporeactivity to re-induction of IFN, the subsequent 6 doses stimulated the formation of IFN at 3685 units/ml on average after each injection, strongly suggesting that IFN plays a role in the antitumoral effect of poly (I):(C).Keywords
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