INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACID
- 1 February 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 62 (2) , 357-361
- https://doi.org/10.1073/pnas.62.2.357
Abstract
The synthetic double-stranded RNA, polyinosinic-cytidylic acid, inhibits the growth of some tumors in mice. Two days after implantation of a reticulum cell sarcoma, a lymphatic lymphoma, a fibrosarcoma, two leukemias, and a human adenovirus 12-induced tumor, treatment of groups of mice resulted in decreased growth rates of the tumors and increased survival times of the animals. In the two tumors tested (the reticulum cell sarcoma and the adenovirus 12-induced tumor) initiation of treatment after the tumor was grown to moderate size caused a regression of the tumor. In the case of the reticulum cell sarcoma, the tumor had not reappeared in some of the animals two months after cessation of treatment.Keywords
This publication has 13 references indexed in Scilit:
- Molecular basis of the action of interferonJournal of Molecular Biology, 1968
- Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.Proceedings of the National Academy of Sciences, 1967
- Molecular basis of interferon action: Inhibition of viral RNA translationVirology, 1966
- Concerning the mechanism of action of interferon.Proceedings of the National Academy of Sciences, 1966
- Interferon and Uninfected Cells.Experimental Biology and Medicine, 1966
- Effect of FUDR on Interferon Production,Experimental Biology and Medicine, 1965
- Inhibition of interferon action by actinomycinBiochemical and Biophysical Research Communications, 1964
- Foreign Nucleic AcidsScientific American, 1963
- INTERFERON AS A CHEMICAL INTERMEDIARY IN VIRAL INTERFERENCE*Annals of the New York Academy of Sciences, 1960
- Normal and Pathologic Anatomy of the Reticular Tissue in Laboratory Mice, With a Classification and Discussion of NeoplasmsJNCI Journal of the National Cancer Institute, 1954