PREOPERATIVE PROSTATE NEEDLE BIOPSY p27 CORRELATES WITH SUBSEQUENT RADICAL PROSTATECTOMY p27, GLEASON GRADE AND PATHOLOGICAL STAGE
- 1 December 2000
- journal article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 164 (6) , 1987-1991
- https://doi.org/10.1016/s0022-5347(05)66934-0
Abstract
Conclusions Expression of p27 in prostate biopsies can be used to predict the degree of expression in radical prostatectomy specimens. As loss of p27 protein expression in prostatectomy specimens has been shown to correlate with biochemical recurrence and shortened prostate specific survival, these results suggest that biopsy p27 may help identify high risk patients preoperatively.Keywords
This publication has 13 references indexed in Scilit:
- P53 AND BCL-2 IMMUNOHISTOCHEMISTRY IN PRETREATMENT PROSTATE NEEDLE BIOPSIES TO PREDICT RECURRENCE OF PROSTATE CANCER AFTER RADICAL PROSTATECTOMYJournal of Urology, 1999
- PREOPERATIVE p53, bcl-2, CD44 and E-CADHERIN IMMUNOHISTOCHEMISTRY AS PREDICTORS OF BIOCHEMICAL RELAPSE AFTER RADICAL PROSTATECTOMYJournal of Urology, 1999
- Down-Regulation of p27 Is Associated with Development of Colorectal Adenocarcinoma MetastasesThe American Journal of Pathology, 1998
- Distinct Altered Patterns of p27KIP1 Gene Expression in Benign Prostatic Hyperplasia and Prostatic CarcinomaJNCI Journal of the National Cancer Institute, 1998
- Association of p27Kipl Levels With Recurrence and Survival in Patients With Stage C Prostate CarcinomaJNCI Journal of the National Cancer Institute, 1998
- PROSTATE-SPECIFIC ANTIGEN AFTER ANATOMIC RADICAL RETROPUBIC PROSTATECTOMYUrologic Clinics of North America, 1997
- Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomasNature Medicine, 1997
- Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patientsNature Medicine, 1997
- 5-Year Tumor Recurrence Rates After Anatomical Radical Retropubic Prostatectomy For Prostate CancerJournal of Urology, 1994
- Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsCell, 1994