N-Acetylneuraminic Acid: Neoglycoproteins and Pseudopolysaccharides
- 1 March 1987
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 6 (1) , 161-165
- https://doi.org/10.1080/07328308708058867
Abstract
A simplified procedure for the synthesis of acetochloroneuraminic acid is described starting from the methyl ester. N-acetyl neuraminic acid α-allyl glycoside was prepared in high yield using silver salicylate as catalyst. Reductive ozonolysis of the allyl group, followed by direct reductive ami nation to protein carriers, gave immunogenic neoglycoproteins. Copolymerization of the α-allyl glycoside with acrylamide produced a water-soluble pseudopolysaccharide useful for the EL ISA technique.Keywords
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