Exposure to selected fragrance materials

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Abstract
The aim of the present study was to assess exposure to constituents of the fragrance mix from cosmetic products used by fragrance‐mix‐positive eczema patients. 23 products, which had either given a positive patch and/or use test in a total of 11 fragrance‐mix‐positive patients, were analyzed. In all cases, the use of these cosmetics completely or partly explained present or past episodes of eczema. Between 1 to 6 constituents of the fragrance mix were found in 22 out of 21 products. The cosmetics of all the patients sensitive to hydroxycitronellal, eugenol, cinnamic alcohol and α‐ amylcinnamic aldehyde were found to contain the respective substances. Exposure concentrations were seen in cover a large range. The content of hydroxycitronellal was, on average, 5×higher in cosmetics from hydroxycitronellal‐sensitive patients, compared to cosmetics from hydroxycitronellal‐negative patients. It is concluded that exposure to constituents of the fragrance mix is common in fragrance‐allergic patients with cosmetic eczema, and that the fragrance mix is a good relied inn of actual exposure.