Effect of prostaglandins on mucosal blood flow and aspirin-induced damage in the canine stomach.

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Abstract
This study deals with the action in anesthetized dogs of prostaglandin [PG] E2 and F2.alpha. given into the celiac artery and the femoral vein on gastric mucosal blood flow, and on gastric mucosal damage induced by aspirin. In the non-stimulated stomach, infusion of PGE2 or F2.alpha. into the celiac artery resulted in a marked increase in mucosal blood flow and a sustained decrease, respectively. Infusion of PGE2 into the femoral vein produced a decrease in mucosal blood flow, whereas PGF2.alpha. produced a biphasic response: a transient increase followed by a decrease. I.v. infused PGE2, while reducing mucosal blood flow, significantly diminished mucosal lesions, altered transmucosal potential differences and H+ back-diffusion induced by a topical application of aspirin. Evidently, the action of PG on gastric mucosal blood flow alters depending on the route of administration. PG seem to exert gastric cytoprotection through mechanisms other than an increase in mucosal blood flow.