Non‐ossifying fibroma or benign lipoblastoma of bone–an electron‐microscopic and histochemical study

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Abstract
An ultrastructural and histochemical analysis was made of a lesion identified by light microscopy as a non‐ossifying fibroma of bone. A histogenetic sequence was traced from spindle‐shaped fibroblast‐like cells to multivacuolated lipoblasts with abundant glycogen. These lipid‐laden cells showed remarkable similarity to some cells of a well differentiated liposarcoma. Others have interpreted the lipid‐containing cells of non‐ossifying fibroma as representing fibroblasts which have imbibed or synthesized lipid or lipid‐laden macrophages. Our studies demonstrate that this tumour consists of primitive mesenchymal cells with partial maturation to early lipoblasts, suggesting its classification as a benign lipoblastoma of bone.

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