Immunological Relationship among Adenoviruses of Humans, Simians, and Nonprimates as Determined by the Neutralization Test

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Abstract
98 antisera prepared against 25 simian adenoviruses and 31 adenovirus types from various nonprimate mammals and birds were tested for their ability to neutralize 35 human adenovirus prototypes. Antisera to these human adenovirus types were similarly tested against 25 simian adenovirus prototypes. Although very few reactions to the human adenoviruses were found in antisera to nonprimate viruses, cross-reactions among the simian and human adenoviruses were more frequent. The majority of these reactions, however, were of low titer and of questionable significance. Two chimpanzee adenovirus strains – Pan 9 and SAV 21 (C 1) – were found with an immunological relationship to human adenoviruses: Pan 9 strain showed a two-way cross relationship to human adenovirus 4, and SAV 21 (C 1) was neutralized by antisera prepared against human adenoviruses 14 and 16.