Regulation of Erythropoiesis
- 24 March 1977
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 296 (12) , 685-687
- https://doi.org/10.1056/nejm197703242961210
Abstract
The renewal rate of adult human red cells in the peripheral circulation is approximately 0.8 per cent per day. If a person is either bled or exposed to a hypoxic environment, erythropoiesis increases as measured by the uptake of 59Fe in newly formed red cells or by the daily output of reticulocytes. The increase is roughly proportional to the degree of anemia or hypoxia. The mediator of this erythropoietic response to anemic or hypoxic hypoxia is erythropoietin,1 a glycoprotein elaborated by the kidney in the adult and by the liver in the fetus.2 The hormone is not yet purified (though . . .Keywords
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