Leuprolide Acetate Therapy in Luteinizing Hormone–Dependent Cushing's Syndrome

Open Access
Publisher Website
Google Scholar
Abstract
Corticotropin-independent Cushing's syndrome is usually caused by cortisol-secreting adrenal adenomas, carcinomas, or (rarely) bilateral adrenal hyperplasia. In some patients with this syndrome, the excess secretion of cortisol is caused by abnormal adrenal expression and function of receptors for various hormones, including gastric inhibitory polypeptide,1-6 vasopressin,7-9 β-adrenergic agonists,10 and interleukin-1.11 These findings suggest that diverse other hormone receptors could be implicated in other patients.12