Traumatic and Toxic Production of Urinary Calculi in Animal Experiment

Publisher Website
Google Scholar
Abstract
Grossmann tested experimentally the theory that the increase of lithiasis in certain parts of Central Europe is due to increased traumatization of the kidneys and increased inhalation of motor car exhaust gases. Albino rats weighing approx. 40 gs. were used. The animals of group 1 were shaken by means of a mechanical shaking apparatus (100 to 120 horizontal vibrations/min.), for 5-7 mins., 2-3 times a wk. over a period of 100-120 days. The animals of group 2 were placed in an airtight glass container, big enough for a sufficient supply of O2. Exhaust gas was collected from the exhaust pipe of a motor car. The animals were exposed to the gas for 15-30 mins., 2-3 times/wk. over a period of 100-120 days. In contrast to controls, 6 of 28 rats exposed to shaking and 5 of 28 rats exposed to exhaust gas showed calculi. Some of the animals developed macroscopic or microscopic hematuria. The significance of the findings is discussed.