Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents
Top Cited Papers
- 26 November 2007
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 46 (46) , 8748-8758
- https://doi.org/10.1002/anie.200701342
Abstract
The 3,3′‐pyrrolidinyl‐spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.Keywords
This publication has 146 references indexed in Scilit:
- p53 – ein natürlicher Krebskiller: Einsichten in die Struktur und TherapiekonzepteAngewandte Chemie, 2006
- Determinants of Specificity of MDM2 for the Activation Domains of p53 and p65: Proline27 Disrupts the MDM2-Binding Motif of p53Biochemistry, 2006
- Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 InteractionJournal of Medicinal Chemistry, 2006
- Discovery of an Inhibitor of a Transcription Factor Using Small Molecule Microarrays and Diversity-Oriented SynthesisJournal of the American Chemical Society, 2003
- Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric MacrobeadsAngewandte Chemie International Edition in English, 2001
- Ein einfacher Zugang zu den tetracyclischen Vorläufern der Hetero- und Secoyohimbane, Strychnos- und OxindolalkaloideEuropean Journal of Organic Chemistry, 1994
- Oxidative Transformations of Indole Alkaloids. II. The Preparation of Oxindoles from cis-DE-Yohimbinoid Alkaloids. The Partial Synthesis of CarapanaubineJournal of the American Chemical Society, 1963
- Oxindole Alkaloids. I. Oxidative-Rearrangement of Indole Alkaloids to their Oxindole AnalogsJournal of the American Chemical Society, 1962
- The Conversion of Tetrahydro-β-Carboline Alkaloids into Oxindoles. the Structures and Partial Syntheses of Mitraphylline and RhyncophyllineJournal of the American Chemical Society, 1962
- Oxindole Analogs of (5-Hydroxy)-tryptamine and -tryptophan, as Inhibitors of the Biosynthesis and Breakdown of Serotonin1Journal of the American Chemical Society, 1958