THE EFFECT OF PITRESSIN ON THE RENAL RESPONSE TO SALT LOADING IN THE RAT

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Abstract
The effect of Pitressin on the renal response to a salt load was studied in normotensive and hypertensive rats. Hypertension was induced by DC A, Compound F, or renal compression. Renal function under load was studied by administering inulin together with a salt load. The effect of 2 IU or Pitressin given subcutaneously was studied at 2 periods, 45 minutes and 3 hours after injection. The first phase of Pitressin action was characterized, as before, by an increase in the excretion of Na and water. While this was qualitatively similar in all experiments, the degree of response varied greatly, being least evident in rats with Compound F hypertension. The data indicate that a large increase in excretion involves a decrease in the tubular reabsorption of Na and water. The second phase of Pitressin action was characterized, as before, by conspicuous Na and water retention.