Independence of Pressor and Depressor Effects of Pitressin in the Rat

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Abstract
Rats made hypertensive with DCA were injected daily with 2 I.U. of Pitres-sln either subcutaneously or intraperitoneally. A detailed electromanometric study of the blood pressure was made fol-lowing the 8th injection. The previously described delayed depressor response which begins 3-5 hours after injection and lasts until the 9th post-injection hour was shown to follow subcutaneous but not intraperltoneal injection. These experiments are considered to support the contention that the pressor and depressor effects are independent and possibly due to separate agents. Rats made hypertensive with Compound F acetate are particularly sensitive to the depressor effects of Pitressin. This was shown by the complete restoration of the blood pressure to normotensive levels following 8 daily subcutaneous injections of 2 I.U. of Pltressin. It was also shown by a marked and prolonged depressor response following a single subcutaneous injection of 2 I.U. of Pitressin.

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