RESPONSE: Re: Polymorphisms of Death Pathway Genes FAS and FASL in Esophageal Squamous-Cell Carcinoma
Open Access
- 5 October 2004
- journal article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 96 (19) , 1479
- https://doi.org/10.1093/jnci/djh290
Abstract
Recently, we reported a statistically significant association between genetic polymorphisms in the death pathway genes FAS and FASL and risk of esophageal squamous-cell carcinoma among the Chinese (1). Krippl et al. now extend the results to breast cancer, showing a similar association between the FAS –1377G>A polymorphism and risk of the cancer among Caucasians. However, they did not observe the same effect for the other two functional polymorphisms, FAS –670A>G and FASL –844C>T. There are several possible explanations for the inconsistent results between their study on breast cancer and our study on esophageal squamous-cell carcinoma.Keywords
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