Preponderance of Thiopurine S-Methyltransferase Deficiency and Heterozygosity Among Patients Intolerant to Mercaptopurine or Azathioprine
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- 15 April 2001
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 19 (8) , 2293-2301
- https://doi.org/10.1200/jco.2001.19.8.2293
Abstract
PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and to evaluate their cl...Keywords
This publication has 34 references indexed in Scilit:
- Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cellsPharmacogenetics and Genomics, 1999
- Thiopurine methyltransferase alleles in British and Ghanaian populationsHuman Molecular Genetics, 1999
- Polymorphism of the thiopurine S-methyltransferase gene in African- AmericansHuman Molecular Genetics, 1999
- Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from AzathioprineAnnals of Internal Medicine, 1998
- Genotypic and phenotypic analysis of the polymorphic thiopurine S‐methyltransferase gene (TPMT) in a European populationBritish Journal of Pharmacology, 1998
- Pharmacogenetics of Cancer Therapy: Getting PersonalAmerican Journal of Human Genetics, 1998
- Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms*Clinical Pharmacology & Therapeutics, 1997
- Enhanced proteolysis of thiopurine S -methyltransferase (TPMT) encoded by mutant alleles in humans ( TPMT ∗ 3 A , TPMT ∗ 2 ): Mechanisms for the genetic polymorphism of TPMT activityProceedings of the National Academy of Sciences, 1997
- Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine IntoleranceAnnals of Internal Medicine, 1997
- A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.Proceedings of the National Academy of Sciences, 1995