An Improved Method for the Preparative Isolation of the S-Carboxymethyl Derivative Chains of Human Fibrinogen

Abstract
An automated procedure for the preparative isolation of the S-carboxymethyl derivative chains of human fibrinogen on carboxymethyl cellulose is described. This involves the use of an apparatus which automatically controls the ion exchange chromatography elution gradient. This technique is advantageous in that it minimizes the need for rechromatography of the various fractions, and is more reproducible than previous techniques.