Protective efficacy of different cell-wall fractions ofMycobacterium tuberculosis

1 December 1992

journal article
research article
Published by Springer Nature in Folia Microbiologica

Vol. 37 (6) , 407-412
https://doi.org/10.1007/bf02899898

Abstract

Immunization with various cell-wall fractions ofM. tuberculosis H₃₇Ra, progressively depleted of lipids (cell-wall-insoluble fraction; CWIF), soluble proteins (cell-wall core; CWC), mycolic acids and arabinogalactans (cell-wall-protein-peptidoglycan complex; CW-PPC) elicited significant levels of both humoral and cell-mediated immune response. Mice immunized with these fractions, when challenged with an LD₅₀ dose ofM. tuberculosis H₃₇Rv, exhibited significant protection as revealed by high survival rates and decreased bacterial load in lungs, liver and spleen, as compared to nonimmunized animals.

Keywords

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