Ultrasonographic Screening for Fetal Aneuploidy

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Abstract
For decades, a maternal age of more than 35 years on the expected date of delivery has been an accepted indication for amniocentesis for fetal karyotyping, given the moderate increase in fetal aneuploidy associated with advancing maternal age. More recently, interest has grown in screening tests that might facilitate the diagnosis of fetal aneuploidy in women otherwise at low risk without excessive invasive testing. So-called triple screening is based on an association between fetal aneuploidy and a combination of low concentrations of alpha-fetoprotein and unconjugated estriol and high concentrations of chorionic gonadotropin in maternal serum. The sensitivity of this method . . .