Persistent activity modification of phosphatidate phosphohydrolase and fatty acyl-CoA synthetase on incubation of adipocytes with the tumour promoter 12-O -tetradecanoylphorbol 13-acetate
- 7 January 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 179 (2) , 351-354
- https://doi.org/10.1016/0014-5793(85)80549-4
Abstract
Incubation of rat adipocytes with the phorbol ester TPA caused a dose-dependent, persistent increase in phosphatidate phosphohydrolase activity and decrease in fatty acyl-CoA synthetase activity. Half-maximal effects were obtained with 1–2 × 10−10 M TPA. TPA did not alter basal or noradrenaline-stimulated lipolysis. It is suggested that these two enzymes might be modified by protein kinase C.Keywords
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