A NEW HYPERVARIABLE MARKER FOR THE HUMAN ALPHA-GLOBIN GENE-CLUSTER
- 1 September 1988
- journal article
- research article
- Vol. 43 (3) , 249-256
Abstract
We have located a highly polymorphic region of DNA approximately 100 kb upstream of the human .alpha.-globin genes (the .alpha.-globin 5'' hypervariable region; 5''HVR). The element responsible is a minisatellite sequence comprising a variable copy number tandem repeat array of a G/Crich 57-bp sequence. This increases the number of minisatellite elements in the vicinity of the .alpha.-globin genes to five, all of which share a region of sequence identity, thus raising questions concerning the distribution and origins of such tandem repeat sequences . The 5''HVR is highly polymorphic and, together with other hypervariable regions at this locus, provides a valuable genetic marker on the short arm of chromosome 16.This publication has 28 references indexed in Scilit:
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