Studies in the biochemistry of micro-organisms. 87. Dihydrogladiolic acid, a metabolic product of Penicillium gladioli Machacek
- 1 March 1952
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 50 (5) , 635-647
- https://doi.org/10.1042/bj0500635
Abstract
A hitherto undescribed mold metabolic product, dihydrogladiolic acid, was isolated from culture filtrates of P. gladioli grown on a modified Raulin-Thom solution. It is believed to be 5-formyl-6-hydroxymethyl-2-methoxy-3-methylbenzoic acid. Physical and chemical properties were detd. Dihydrogladiolic acid is readily oxidized in vitro to gladiolic acid by heating with KIO4 in dilute sulfuric acid soln. Gladiolic acid is believed to be 5,6-diformyl-2-methoxy-3-methylbenzoic acid, or its tautomer. Cyclopolic and cyclopaldic acids from P. cyclopium are thus 4-hydroxydihydrogladiolic acid and 4-hydroxygladiolic acid, respectively.Keywords
This publication has 3 references indexed in Scilit:
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- Gladiolic acid, a metabolic product of Penicillium gladioli. 1. StructureBiochemical Journal, 1952
- Studies in the biochemistry of micro-organisms. 86. The molecular constitution of mycophenolic acid, a metabolic product of Penicillium brevi-compactum Dierckx. Part 3. Further observations on the structural formula for mycophenolic acidBiochemical Journal, 1952