Dichain Structure of Botulinum Neurotoxin: Identification of Cleavage Sites in Types C, D, and F Neurotoxin Molecules
- 1 November 1999
- journal article
- Published by Springer Nature in Protein Journal
- Vol. 18 (8) , 885-892
- https://doi.org/10.1023/a:1020687430927
Abstract
Botulinum neurotoxin (NT) is synthesized by Clostridium botulinumas about a 150-kDa single-chain polypeptide. Posttranslational modification by bacterial or exogenous proteases yielded dichain...Keywords
This publication has 30 references indexed in Scilit:
- Molecular Construction of Clostridium botulinum Type C Progenitor Toxin and Its Gene OrganizationBiochemical and Biophysical Research Communications, 1994
- Covalent structure of botulinum neurotoxin type A: Location of sulfhydryl groups, and disulfide bridges and identification of C-termini of light and heavy chainsProtein Journal, 1994
- Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevinNature, 1992
- Sequence of the gene encoding type F neurotoxin ofClostridium botulinumFEMS Microbiology Letters, 1992
- Sequences of the botulinal neurotoxin E derived from Clostridium botulinum type E (strain beluga) and Clostridium butyricum (strains ATCC 43181 and ATCC 43755)Biochemical and Biophysical Research Communications, 1992
- Botulinum neurotoxin type A: sequence of amino acids at the N-terminus and around the nicking siteBiochimie, 1990
- Nicking of single chain Clostridiumbotulinum type A neurotoxin by an endogenous proteaseBiochemical and Biophysical Research Communications, 1989
- A common subunit structure in Clostridium botulinum type A, B and E toxinsBiochemical and Biophysical Research Communications, 1972
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- A procedure for the isolation of deoxyribonucleic acid from micro-organismsJournal of Molecular Biology, 1961